In determining the potency of antagonist drugs on blockade of a particular receptor, the antagonist has to be tested in the presence of a selective agonist drug for the receptor of interest. However, the antagonist’s potency can only be accurately determined when the agonist concentration-response curves are constructed in the absence and presence of increasing concentration of the antagonist. This is the method devised by Schild (Arunlakshana & Schild, 1959), which is routinely used in pharmacological research to determine the apparent pA2 or potency of antagonist drugs.


Clinical Questions Worksheet

Presented below are clinical reasoning questions intended for use by practitioners, clinicians, and supervisors. These questions may be applied throughout a person’s service process. Answers to these questions can help guide the clinical case formulation for a person receiving services as well as guide intervention planning, implementation, and completion of interventions. These questions work well in group supervision situations that involve case presentation and analysis

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Goal Logic Worksheet

This worksheet is designed to help conceptualize and organize intervention planning for a person receiving services. It links together the Life Change Goals planned with and for the person, the early thinking about Intervention Strategies that will be used to bring about desired outcomes/ life changes, and possible ideas for Actions that could be planned to implement intervention strategies.

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Intervention Planning Worksheet

Mateo says his wellness and recovery goals are: • Getting my health issues under control. • Being clean and staying sober. • Supplementing my current income with paid part-time work. • Fathering my four-year-old son, Pepe, like a real dad. • Building relationships with my older children. • Participating in church activities and continuing his spiritual journey to get to a better place in life. • Getting a bigger apartment so that Pepe can come stay with me on weekends. • Having a stable, healthy relationship with a good woman who doesn't use substances and who likes me for who I am and who I am becoming.

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Mateo’s Situation: Life History & Present Circumstances

The case simulation involves a man named Mateo who is served for serious physical health issues, substance abuse, and mental health needs. Details are provided through documents reflecting information in his chart and conversation with providers. Your task is to organize and rely on the available information to complete the organizers and tools provided for building a strong Clinical Reasoning and Case Formulation process. Some information you would like to have may not be available in a brief written simulation.

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Bioethics and Human Rights

In Melnyk & Fineout-Overholt (2019) textbook Box 23.1 (chapter 23), select one of the Fifteen Ethical Principles of the Universal Declaration on Bioethics and Human Rights. o Then state the principle and describe the importance of the selected principle to ethical research. o In addition, describe how a researcher would ensure that this principle would be protected for human subjects in a research study.

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Eating Disorder

Design a 12-15 slide PowerPoint that highlights a specific personality disorder. Include the following: Discuss specific aspects of the personality disorder you selected, including how the disorder is assessed. Does the disorder have a genetic predisposition? Explain. Discuss brain and neurochemical features related to the disorder. Explain personality characteristics that relate to the disorder. Explain cognitive features that relate to the disorder

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Ethics Discussion

You are called to problem-solve a situation between a patient and a staff nurse. The patient is refusing to allow the nurse to take care of him because the patient believes the nurse is of a different religion he is unfamiliar with. How will you handle the situation? How will you intervene in a culturally competent way?

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