ALZHEIMER’S DISEASE

Dementia occurs in various forms, with the most common being Alzheimer’s disease (AD). AD is a degenerative neurological condition that is marked by gradual loss of memory, which occurs due to buildup of plaque in the brain, particularly the toxic amyloid ? peptides. This accumulation in the brain is majorly attributed to genetic predispositions (70%) and environmental factors (30%) like age, head trauma, level of fitness, and cardiovascular infections.

It is noted that the disease is most prevalent to patients older than 65 years of age, with late-onset Alzheimer’s disease (LOAD) and Sporadic Alzheimer’s disease (SAD) accounting for more than 99% of AD. Research studies indicate that predisposition of a person to SAD is influenced by various genes, nonetheless, there is insufficient documentation on these genes. Sufficient documentation only exists for the ?4 allele (APOE gene). 

Genome-wide association studies depend on the statistics for phenotypic/genotypic identification...